Substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones with antitumor activity. In depth study of the effect on growth of breast cancer cells.

  title={Substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones with antitumor activity. In depth study of the effect on growth of breast cancer cells.},
  author={Aldo Andreani and Stefania Bellini and Silvia Burnelli and Massimiliano Granaiola and Alberto Leoni and Alessandra Locatelli and Rita Morigi and Mirella Rambaldi and Lucilla Varoli and Natalia Calonghi and Concettina Cappadone and Maddalena Zini and Claudio Stefanelli and Lanfranco Masotti and Robert H. Shoemaker},
  journal={Journal of medicinal chemistry},
  volume={53 15},
The synthesis of new substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones is reported. The antitumor activity was evaluated according to protocols available at the National Cancer Institute (NCI), Bethesda, MD. Structure-activity relationships are discussed. The action of selected compounds was investigated in MCF-7 breast cancer cells. The ability of these derivatives to inhibit cellular proliferation was accompanied by increased level of p53 and its transcriptional targets p21 and Bax… 

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