Substituted thiazoles VI. Synthesis and antitumor activity of new 2-acetamido- and 2 or 3-propanamido-thiazole analogs.

@article{ElMessery2012SubstitutedTV,
  title={Substituted thiazoles VI. Synthesis and antitumor activity of new 2-acetamido- and 2 or 3-propanamido-thiazole analogs.},
  author={S. El-Messery and Ghada S Hassan and Fatmah A. M. Al-Omary and H. El-Subbagh},
  journal={European journal of medicinal chemistry},
  year={2012},
  volume={54},
  pages={
          615-25
        }
}
A novel series of 2-acetamido and 2 or 3-propanamido derivatives of 4- or 5-substituted-thiazoles was designed and synthesized. Structure elucidation of the new synthesized compounds was attained by the use of (1)H &(13)C NMR, and Mass spectrometry. Compounds were subjected to NCI in vitro assessment for their antitumor activity, at a single dose of 10 μM of test compounds. Compounds bearing straight chain substituent or 4-phenyl function proved to be more active than their branched or 4-methyl… Expand
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