Substituted diaryl diselenides: cytotoxic and apoptotic effect in human colon adenocarcinoma cells.

@article{Nedel2012SubstitutedDD,
  title={Substituted diaryl diselenides: cytotoxic and apoptotic effect in human colon adenocarcinoma cells.},
  author={Fernanda Nedel and Vin{\'i}cius Farias Campos and Diego Cardoso Alves and Alan J. A. McBride and Odir Antonio Dellagostin and Tiago Collares and Lucielli Savegnago and Fabiana K{\"o}mmling Seixas},
  journal={Life sciences},
  year={2012},
  volume={91 9-10},
  pages={345-52}
}
AIMS To investigate the effects and study the underlying cell death mechanisms of diaryl diselenides, including: diphenyl diselenide (C(6)H(5)Se)(2); 4-chlorodiphenyl diselenide (4-ClC(6)H(4)Se)(2); 3-(trifluoromethyl)-diphenyl diselenide (3-CF(3)C(6)H(4)Se)(2) and 4-methoxydiphenyl diselenide (4-MeOC(6)H(4)Se)(2), on the human colon adenocarcinoma cell line HT-29. MAIN METHODS The viability of HT-29 cells after exposure to the diaryl diselenides and its substituted structures was based on… CONTINUE READING

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