Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase

@article{Fellenius1981SubstitutedBI,
  title={Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase},
  author={E. Fellenius and T. Berglindh and G. Sachs and L. Olbe and B. Elander and Sven-Erik Sj{\"o}strand and B. Wallmark},
  journal={Nature},
  year={1981},
  volume={290},
  pages={159-161}
}
  • E. Fellenius, T. Berglindh, +4 authors B. Wallmark
  • Published 1981
  • Medicine, Chemistry
  • Nature
  • Studies both in vivo1,2 and in vitro1–5 have shown that substituted benzimidazoles inhibit the stimulation of acid secretion produced by dibutyryl cyclic AMP and histamine. Furthermore, the results differ from those produced by H2 antagonists and anticholinergic agents in that the inhibition is not competitive, and the site of action is intracellular and peripheral to that of dibutyryl cyclic AMP. To investigate the biochemical mechanism of action of substituted benzimidazoles, one such… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 250 CITATIONS, ESTIMATED 66% COVERAGE

    Effect of Acetazolamide and Melittin on Polarization of the Frog Gastric Mucosa Proton Pump

    • Gaspar Carrasquer, Manuel Schwartz
    • Biology, Chemistry, Medicine
    • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
    • 1996

    Cyclic GMP and acid production in isolated gastric cells of the rat

    Pharmacology of proton pump inhibitors

    Positive modulation of pepsinogen secretion by gastric acidity after vagal cholinergic stimulation.

    VIEW 2 EXCERPTS
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    1983
    2020

    CITATION STATISTICS

    • 7 Highly Influenced Citations

    • Averaged 6 Citations per year from 2018 through 2020