Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase

  title={Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase},
  author={Erik Fellenius and Thomas Berglindh and George Sachs and Lars Olbe and Berit Elander and Sven-Erik Sj{\"o}strand and Bj{\"o}rn Wallmark},
Studies both in vivo1,2 and in vitro1–5 have shown that substituted benzimidazoles inhibit the stimulation of acid secretion produced by dibutyryl cyclic AMP and histamine. Furthermore, the results differ from those produced by H2 antagonists and anticholinergic agents in that the inhibition is not competitive, and the site of action is intracellular and peripheral to that of dibutyryl cyclic AMP. To investigate the biochemical mechanism of action of substituted benzimidazoles, one such… CONTINUE READING
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