Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase

@article{Fellenius1981SubstitutedBI,
  title={Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase},
  author={E. Fellenius and T. Berglindh and G. Sachs and L. Olbe and B. Elander and Sven-Erik Sj{\"o}strand and B. Wallmark},
  journal={Nature},
  year={1981},
  volume={290},
  pages={159-161}
}
Studies both in vivo1,2 and in vitro1–5 have shown that substituted benzimidazoles inhibit the stimulation of acid secretion produced by dibutyryl cyclic AMP and histamine. Furthermore, the results differ from those produced by H2 antagonists and anticholinergic agents in that the inhibition is not competitive, and the site of action is intracellular and peripheral to that of dibutyryl cyclic AMP. To investigate the biochemical mechanism of action of substituted benzimidazoles, one such… Expand
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