Substituted aryl malonamates as new serine beta-lactamase substrates: structure-activity studies.


A series of substituted aryl malonamates have been prepared. These compounds are analogues of aryl phenaceturates where the amido side chain has been replaced by a retro-amide. Like the phenaceturates, these compounds are substrates of typical class A and class C beta-lactamases, particularly of the latter, and of soluble DD-peptidases. The effect of… (More)
DOI: 10.1016/j.bmc.2009.10.056


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