Substituted aniline interaction with submitochondrial particles and quantitative structure-activity relationships.

@article{Argese2002SubstitutedAI,
  title={Substituted aniline interaction with submitochondrial particles and quantitative structure-activity relationships.},
  author={Emanuele Argese and Cinzia Bettiol and Matteo Fasolo and Alfonso Zambon and Francesca Agnoli},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1558 2},
  pages={151-60}
}
The toxic effects of eighteen substituted anilines were determined by means of a short-term in vitro assay, using submitochondrial particles (SMP) as biosensors. The assay allows for the quantification of the effects of toxicants that act specifically on mitochondrial respiratory functions, like uncouplers and inhibitors, or non-specifically, by disturbing the structure and functioning of the inner mitochondrial membrane. The obtained EC(50) values range from 72.5 to 1910 micromol/l. The type… CONTINUE READING