Substantial spontaneous long-term remission in subacute sclerosing panencephalitis (SSPE)

@article{Santoshkumar1998SubstantialSL,
  title={Substantial spontaneous long-term remission in subacute sclerosing panencephalitis (SSPE)},
  author={Balagopal Santoshkumar and Kurupath Radhakrishnan},
  journal={Journal of the Neurological Sciences},
  year={1998},
  volume={154},
  pages={83-88}
}
We report a 25-year-old female who developed clinical and electroencephalographic (EEG) features of subacute sclerosing panencephalitis (SSPE) at the age of 17 years. After almost 17 months of progressive neurological deterioration to a level where she was bedridden and incapable of self-care (Risk and Haddad stage 3a), she experienced a substantial spontaneous clinical and EEG remission (stage 4c) which she has maintained for the last 8 years. The measles antibody titer in the cerebrospinal… Expand
Long term survival in subacute sclerosing panencephalitis: An enigma
TLDR
The observations suggest that SSPE may have a highly variable clinical course and warrants cautious approach for counseling at initial evaluation and while interpreting beneficial effect of disease modifying agent(s). Expand
Substantial Remission in Subacute Sclerosing Panencephalitis by Following the Ketogenic Diet: A Case Report
TLDR
KD has an anti-inflammatory effect and can halt and reverse neurodegenerative changes and its neuroprotective effects could be due to the reduced oxidative stress, enhanced mitochondrial activity, and the suppression of pro-apoptotic factors. Expand
Subacute Sclerosing Panencephalitis (SSPE): A Fatal Aftermath of Measles Infection
Subacute Sclerosing Panencephalitis (SSPE) is a progressive form of encephalitis without a cure. This case report pertains to a primigravida diagnosed with SSPE in her fifth month of pregnancy. SheExpand
Adult-Onset Subacute Sclerosing Panencephalitis With Biphasic Course: Case Report
TLDR
Hastayi hastaliginin ikinci fazinda 27 yasinda iken gordugumuzde, ne myoklonus ne de elektroensefalografisinde (EEG) periyodik keskin ve yavas dalga desarjlari vardi. Expand
Long-term follow-up of patients with adult-onset subacute sclerosing panencephalitis
TLDR
It is suggested that isoprinosine alone or in combination with intraventricular interferon did not change the prognosis in long-term follow-up periods. Expand
Diagnostic Approaches and Management of Subacute Sclerosing Panencephalitis in Children
TLDR
The topic of SSPE in children is discussed with a major focus on diagnostic and therapeutic approaches based on the latest scientific evidence, which shows that in developing countries it is still quite high compared to developed countries. Expand
Macular Retinitis as a First Sign of Subacute Sclerosing Panencephalitis: The Importance of Early Diagnosis
TLDR
Ophthalmic manifestations, especially macular retinitis, may be useful in the diagnosis and management of SSPE cases with elevated IgG titers for rubeola in CSF. Expand
Macular Retinitis as a First Sign of Subacute Sclerosing Panencephalitis: The Importance of Early Diagnosis
TLDR
It is proposed that ophthalmic manifestations, especially macular retinitis, may be useful in the diagnosis and management of SSPE cases with elevated IgG titers for rubeola in CSF. Expand
Subacute sclerosing panencephalitis
  • R. Garg
  • Medicine
  • Postgraduate medical journal
  • 2002
TLDR
A combination of oral isoprinosine (Inosiplex) and intraventricular interferon alfa appears to be the best effective treatment for subacute sclerosing panencephalitis. Expand
Subacute sclerosing panencephalitis in an identical twin.
TLDR
A case, probably related to the last national measles epidemic in this country, in which an identical twin developed one of the most dreaded long-term sequelae of measles, subacute sclerosing panencephalitis (SSPE). Expand
...
1
2
...

References

SHOWING 1-10 OF 24 REFERENCES
[Prolonged remission in subacute sclerosing panencephalitis: 2 cases].
TLDR
Clinical improvement was observed and periodic EEG complexes disappeared, however, the electrophoretic oligoclonal pattern of CSF proteins and the elevated measles titers persisted (in one case specific CSF IgM were still increased 6 years after the onset). Expand
Long-term survival of a case of subacute sclerosing panencephalitis.
TLDR
A patient who has not only survived for nine years to date, but who has also shown spontaneous clinical, electrophysiological and immunological improvement sustained over the past five years. Expand
Substantial spontaneous long-term improvement in subacute sclerosing panencephalitis. Six cases from the Middle East and a review of the literature.
TLDR
Of 118 cases of subacute sclerosing panencephalitis identified in an extensive follow-up study in the Middle East, six patients were found by personal interview to have experienced substantial spontaneous long-term improvement, and this rate of 5% is presently the most accurate estimate available. Expand
Clinical-electrophysiological correlations in a long-term case of subacute sclerosing panencephalitis with partial clinical improvement.
TLDR
Results indicate that an accurate electrophysiological study (through cerebral evoked potentials) has an important role in investigating suspected cases of SSPE, in following the clinical evolution of this disease and providing prognostic data. Expand
Long-term follow-up of patients with subacute sclerosing panencephalitis treated with intraventricular alpha-interferon
TLDR
Treatment-induced remissions in SSPE can be temporary, analogous to spontaneous remissions, and longer treatment with higher doses, or combinations of drugs, may be required. Expand
The variable natural history of subacute sclerosing panencephalitis: a study of 118 cases from the Middle East.
A variable natural history was found in a standardized follow-up study of 118 patients with subacute sclerosing panencephalitis (SSPE). Only 20% followed the sequence:behavior change, mentalExpand
Subacute sclerosing panencephalitis (SSPE): early diagnosis, prognostic factors and natural history
  • B. Yaqub
  • Medicine
  • Journal of the Neurological Sciences
  • 1996
TLDR
Long VSEEG monitoring greatly improves early diagnosis and detection of subtle atonia or segmental myoclonus and its correlations with EEG periodic complexes. Expand
Long survival in subacute sclerosing panencephalitis.
A case is reported of a boy who at the age of 14 years developed subacute sclerosing panencephalitis. He deteriorated over a period of 9 months, improved greatly and remained stable for 7 yearsExpand
The periodic events of subacute sclerosing leucoencephalitis.
  • W. Cobb
  • Psychology, Medicine
  • Electroencephalography and clinical neurophysiology
  • 1966
Abstract 1. 1. A survey of the periodic EEG changes and the motor events which accompanied them, in twenty cases of subacute sclerosing leucoencephalitis (SSLE), all except three with pathologicalExpand
Periodic electroencephalographic pattern in subacute sclerosing panencephalitis modified by preexisting damaged cerebral hemisphere.
TLDR
The modification of PCs in the authors' patient due to preexisting damaged cerebral hemisphere illustrate that a fairly functional cortex and subcortical white matter are needed for the expression of the PCs of SSPE. Expand
...
1
2
3
...