Substantial proliferation of human renal tubular epithelial cell-reactive CD4+CD28null memory T cells, which is resistant to tacrolimus and everolimus.

Abstract

BACKGROUND In spite of maintenance treatment with immunosuppressive drugs, tubulitis still occurs and can lead to structural kidney graft damage. We hypothesize that human renal tubular epithelial cells (TECs) trigger selective proliferation of recipient T-cell subsets with variable sensitivity to immunosuppressive drugs. METHODS Recipient peripheral… (More)
DOI: 10.1097/01.TP.0000435697.31148.b2

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Cite this paper

@article{Demmers2014SubstantialPO, title={Substantial proliferation of human renal tubular epithelial cell-reactive CD4+CD28null memory T cells, which is resistant to tacrolimus and everolimus.}, author={Martijn W. H. J. Demmers and Carla C. Baan and M J F W Janssen and Nicolle Helena Renier Litjens and Jan N. M. Ijzermans and Michiel Gerardus Henricus Betjes and Willem Weimar and Ajda Tahereh Rowshani}, journal={Transplantation}, year={2014}, volume={97 1}, pages={47-55} }