Substantia nigra pars reticulata is crucially involved in barbiturate and ethanol withdrawal in mice

@article{Chen2011SubstantiaNP,
  title={Substantia nigra pars reticulata is crucially involved in barbiturate and ethanol withdrawal in mice},
  author={Gang Chen and Laura Beth Kozell and Kari J. Buck},
  journal={Behavioural Brain Research},
  year={2011},
  volume={218},
  pages={152-157}
}
Sedative-hypnotic CNS depressant drugs are widely prescribed to treat a variety of disorders, and are abused for their sedative and euphoric effects. Physiological dependence and associated withdrawal episodes are thought to constitute a motivational force that sustains their use/abuse and may contribute to relapse in dependent individuals. Although no animal model duplicates depressant dependence, models for specific factors, like withdrawal, are useful for identifying potential neural… CONTINUE READING
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