Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome.

@article{Godau2007SubstantiaNH,
  title={Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome.},
  author={Jana Godau and Katherine Johanna Schweitzer and Inga Liepelt and Christian Gerloff and D. Berg},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2007},
  volume={22 2},
  pages={187-92}
}
Pathological studies demonstrate a decreased iron content in the substantia nigra (SN) contributing to the pathophysiology of restless legs syndrome (RLS). SN echogenicity as measured by transcranial sonography (TCS) correlates with the SN iron content. The objective of this study was to determine a critical value to define SN hypoechogenicity as a potential marker for RLS. There were 49 RLS patients (39 idiopathic, 10 secondary) and 49 age- and sex-matched controls who underwent TCS by 2… CONTINUE READING

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