Substances with estrogenic activity in effluents of sewage treatment plants in southwestern Germany. 2. Biological analysis.

@article{Krner2001SubstancesWE,
  title={Substances with estrogenic activity in effluents of sewage treatment plants in southwestern Germany. 2. Biological analysis.},
  author={Wolfgang K{\"o}rner and Patricia Spengler and Uwe Bolz and Wolfgang Schuller and Volker Hanf and Joerg W. Metzger},
  journal={Environmental toxicology and chemistry},
  year={2001},
  volume={20 10},
  pages={
          2142-51
        }
}
The proliferation test with human estrogen receptor-positive MCF-7 breast cancer cells (E-Screen assay) was applied for quantitative determination of total estrogenic activity in 24-h composite effluent samples from 16 municipal and two industrial sewage treatment plants (STPs) in the state of Baden-Württemberg, southwestern Germany. The estrogenic efficacy relative to the positive control, 17beta-estradiol, was between 26 and 74% (median, 48%) for the 16 municipal STPs. Estradiol equivalent… CONTINUE READING

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