Substance use and the treatment of resistant depression in adolescents.

  title={Substance use and the treatment of resistant depression in adolescents.},
  author={Benjamin I Goldstein and Wael A. Shamseddeen and Anthony Spirito and Graham J. Emslie and Gregory N. Clarke and Karen Dineen Wagner and Joan Rosenbaum Asarnow and Benedetto Vitiello and Neal D. Ryan and Boris J Birmaher and Taryn L. Mayes and Matthew Onorato and Jamie Zelazny and David A. Brent},
  journal={Journal of the American Academy of Child and Adolescent Psychiatry},
  volume={48 12},
OBJECTIVE Despite the known association between substance use disorders and major depressive disorder (MDD) among adolescents, little is known regarding substance use among adolescents with MDD. METHOD Youths with MDD who had not improved after an adequate selective serotonin reuptake inhibitor trial (N = 334) were enrolled in the Treatment of SSRI-Resistant Depression in Adolescents trial. Analyses examined substance use (via the Drug Use Severity Index) and changes therein in relation to… CONTINUE READING
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