Substance p (SP), neurokinin a (NKA), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in synovial fluid from knee joints in patients suffering from rheumatoid arthritis

@article{Larsson1990SubstanceP,
  title={Substance p (SP), neurokinin a (NKA), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in synovial fluid from knee joints in patients suffering from rheumatoid arthritis},
  author={Jonas Larsson and Anneli Ekblom and Kristina Henriksson and Thomas Lundeberg and Elvar Theodorsson},
  journal={Pain},
  year={1990},
  volume={41}
}
AIM OF INVESTIGATION: Recently the involvement of peptide containing somatic afferent nerve fibers as well as sympathetic efferents in the pathophysiology of joint inflammation has been discussed. A relationship has been found between peptldergic fibers and arthritis in animal models. The presence of the various peptides in normal and inflammed human joints is unknown. We have therefore studied the presence of some peptides, proposed to be of importance in arthritis, in inflammed and non… CONTINUE READING