Substance dependence as a compulsive behavior.

@article{Koob1998SubstanceDA,
  title={Substance dependence as a compulsive behavior.},
  author={G. F. Koob and M Rocio and Anna Maria Carrera and Lisa H. Gold and Charles J Heyser and C. S. Maldonado-Irizarry and Athina Markou and Loren Howell Parsons and Amanda J Roberts and Gery Schulteis and Luis Stinus and John R Walker and Ruth Weissenborn and Friedbert Weiss},
  journal={Journal of psychopharmacology},
  year={1998},
  volume={12 1},
  pages={39-48}
}
A compulsion to take a drug combined with a loss of control in limiting intake is the defining feature of substance dependence or addiction, and is the conceptual framework for the criteria of substance dependence or addiction outlined by the World Health Organization and the American Psychiatric Association. However, defining exactly what constitutes loss of control and compulsive drug taking at the level of animal models is a daunting task, and it is clear that no validated animal model… CONTINUE READING

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