Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro.

@article{Wang2009SubstancePS,
  title={Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro.},
  author={Liping Wang and Rong Zhao and Xiaoyou Shi and Tzuping Wei and Bernard P. Halloran and David J Clark and Christopher Rae Jacobs and Wade S. Kingery},
  journal={Bone},
  year={2009},
  volume={45 2},
  pages={309-20}
}
INTRODUCTION SP is a neuropeptide distributed in the sensory nerve fibers that innervate the medullar tissues of bone, as well as the periosteum. Previously we demonstrated that inhibition of neuropeptide signaling after capsaicin treatment resulted in a loss of bone mass and we hypothesized that SP contributes to bone integrity by stimulating osteogenesis… CONTINUE READING