Substance P stimulates IL-1 production by astrocytes via intracellular calcium.

@article{Martin1992SubstancePS,
  title={Substance P stimulates IL-1 production by astrocytes via intracellular calcium.},
  author={Finbarr C. Martin and Andrew Charles and Michael J. Sanderson and Jean E. Merrill},
  journal={Brain research},
  year={1992},
  volume={599 1},
  pages={13-8}
}
There is increasing evidence that local substance P (SP) exacerbates peripheral inflammations, partly by stimulating production of inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha). SP may play similar roles in certain central nervous system inflammations. Multiple sclerosis plaques, for example, form around veins which are innervated by unmyelinated SP-containing fibers, and astrocytes in multiple sclerosis plaques stain for SP. We tested whether… CONTINUE READING
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