Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture

@article{Li2015SubstancePS,
  title={Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture},
  author={W. -W. Li and T. -Z. Guo and Xiaoyou Shi and Yuan Sun and Tzuping Wei and David J Clark and Wade S. Kingery},
  journal={Neuroscience},
  year={2015},
  volume={310},
  pages={73-90}
}
Tibia fracture in rodents induces substance P (SP)-dependent keratinocyte activation and inflammatory changes in the hindlimb, similar to those seen in complex regional pain syndrome (CRPS). In animal pain models spinal glial cell activation results in nociceptive sensitization. This study tested the hypothesis that limb fracture triggers afferent C-fiber SP release in the dorsal horn, resulting in chronic glial activation and central sensitization. At 4 weeks after tibia fracture and casting… CONTINUE READING
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