Substance P promotes susceptibility to Pseudomonas aeruginosa keratitis in resistant mice: anti-inflammatory mediators downregulated.

@article{McClellan2008SubstancePP,
  title={Substance P promotes susceptibility to Pseudomonas aeruginosa keratitis in resistant mice: anti-inflammatory mediators downregulated.},
  author={Sharon A. McClellan and Yunfan Gerry Zhang and R. Barrett and Linda D Hazlett},
  journal={Investigative ophthalmology & visual science},
  year={2008},
  volume={49 4},
  pages={1502-11}
}
PURPOSE Studies have shown that blocking substance P (SP) binding to neurokinin 1 receptor with spantide I prevents Pseudomonas aeruginosa-induced corneal perforation in susceptible C57BL/6 mice. This study tested the effect of SP injection on the resistance response (cornea heals) of BALB/c mice. METHODS The day before infection, mice were injected intraperitoneally with SP or PBS. Disease was graded by clinical score, slit lamp, plate count, real-time RT-PCR, and ELISA assays, and… CONTINUE READING
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