Substance P primes the formation of hydrogen peroxide and nitric oxide in human neutrophils.

@article{SternerKock1999SubstancePP,
  title={Substance P primes the formation of hydrogen peroxide and nitric oxide in human neutrophils.},
  author={Anja Sterner-Kock and Ruedi K. Braun and Albert van der Vliet and Mark D. Schrenzel and Ruth J Mcdonald and Mahendra B Kabbur and P. Richard Vulliet and Dallas M. Hyde},
  journal={Journal of leukocyte biology},
  year={1999},
  volume={65 6},
  pages={834-40}
}
Substance P (SP), a neurotransmitter of the central and peripheral nervous system, has been implicated as a mediator of the pulmonary inflammatory response through its stimulatory effects on neutrophils. We investigated the role of SP in priming the production of reactive oxygen species by human neutrophils with the cytochrome c reduction assay and by flow cytometry using the intracellular oxidizable probe dichlorofluorescein. We also investigated SP-induced formation of nitrite and nitrate as… CONTINUE READING