Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: a potential component of nociception.

@article{PatteMensah2005SubstancePI,
  title={Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: a potential component of nociception.},
  author={Christine Patte-Mensah and Cherkaouia Kibaly and Ayiko{\'e} Guy Mensah-Nyagan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 25},
  pages={
          9044-9
        }
}
A crucial biochemical reaction in vertebrates is progesterone conversion into neuroactive metabolites such as dihydroprogesterone (5alpha-DHP) and tetrahydroprogesterone (3alpha,5alpha-THP), which regulate several neurobiological processes, including stress, depression, neuroprotection, and analgesia. 3alpha,5alpha-THP is a potent stimulator of type A receptors of GABA, the main inhibitory neurotransmitter. Here, we show that in the spinal sensory circuit progesterone conversion into 5alpha-DHP… Expand
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