Substance P induction of murine keratinocyte PAM 212 interleukin 1 production is mediated by the neurokinin 2 receptor (NK-2R).

@article{Song2000SubstancePI,
  title={Substance P induction of murine keratinocyte PAM 212 interleukin 1 production is mediated by the neurokinin 2 receptor (NK-2R).},
  author={I S Song and Nigel W Bunnett and John E. Olerud and B van Harten and Martin S Steinhoff and Jeffrey R. Brown and K. J. Sung and Cheryl A. Armstrong and John C. Ansel},
  journal={Experimental dermatology},
  year={2000},
  volume={9 1},
  pages={42-52}
}
The neurological system plays an important role in modulating some inflammatory skin diseases. Neuro-cutaneous interactions may be mediated by the release of neuropeptides such as substance P (SP) which activate immunocompetent cells in the skin by binding to high affinity neurokinin receptors (NKR). Since epidermal keratinocytes produce a variety of cytokines and are intimately associated with cutaneous sensory fibers, we tested the ability of these cells to participate in the cutaneous… CONTINUE READING