Corpus ID: 10222953

Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice.

@article{Andoh1998SubstancePI,
  title={Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice.},
  author={T. Andoh and Tetsuro Nagasawa and Masamichi Satoh and Yasushi Kuraishi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={286 3},
  pages={
          1140-5
        }
}
Our experiments were conducted to determine whether substance P (SP) would elicit an itch sensation mediated by mast cells in mice. An intradermal injection of SP (10-135 microgram site-1) into the rostral back of the ICR mouse dose-dependently produced scratching of the injected site. The SP- (135 microgram site-1 = 100 nmol site-1) induced scratching was inhibited by capsaicin (repeated administration) and naloxone; features being similar to itch in humans. SP elicited scratching in mast cell… Expand
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