Substance P induces secretion of immunomodulatory cytokines by human astrocytoma cells

@article{Palma1998SubstancePI,
  title={Substance P induces secretion of immunomodulatory cytokines by human astrocytoma cells},
  author={C. Palma and S. Manzini},
  journal={Journal of Neuroimmunology},
  year={1998},
  volume={81},
  pages={127-137}
}
In human astrocytoma cell lines, substance P (SP) stimulated interleukin (IL)-8, IL-6, granulocyte macrophage colony-stimulating factor and leukemia inhibitory factor protein secretion. These SP effects were blocked by a specific NK1 tachykinin receptor antagonist. Further, SP stimulation increased the half-life of IL-6 and IL-8 messenger RNAs, suggesting that the synthesis of these cytokines is also regulated post-transcriptionally. SP-induced cytokine release was inhibited by staurosporine… Expand
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