Substance P-induced release of prostaglandins from astrocytes: regional specialisation and correlation with phosphoinositol metabolism.

@article{Marriott1991SubstancePR,
  title={Substance P-induced release of prostaglandins from astrocytes: regional specialisation and correlation with phosphoinositol metabolism.},
  author={Denver Marriott and Graham P. Wilkin and John N Wood},
  journal={Journal of neurochemistry},
  year={1991},
  volume={56 1},
  pages={259-65}
}
Addition of substance P (SP) to astrocytes cultured from rat neonatal spinal cord evoked a time- and concentration-dependent increase in the accumulation of phosphoinositol and the release of prostaglandin (PG) D2 and PGE2. Both basal and stimulated releases were reduced to similar levels by indomethacin. In contrast, astrocytes cultured from cerebral cortex and cerebellum showed no SP-stimulated increase in phosphoinositol accumulation or release of PGs. Release of PGD2 and PGE2 was, however… CONTINUE READING

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Addition of substance P ( SP ) to astrocytes cultured from rat neonatal spinal cord evoked a time- and concentration - dependent increase in the accumulation of phosphoinositol and the release of prostaglandin ( PG ) D2 and PGE2 .
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