Substance P-induced calcium entry in endothelial cells is secondary to depletion of intracellular stores.

@article{Sharma1995SubstancePC,
  title={Substance P-induced calcium entry in endothelial cells is secondary to depletion of intracellular stores.},
  author={Nigel R. Sharma and Michael J Davis},
  journal={The American journal of physiology},
  year={1995},
  volume={268 3 Pt 2},
  pages={
          H962-73
        }
}
Substance P (SP) induces an elevation in cytosolic Ca2+ concentration ([Ca2+]i) in porcine coronary artery endothelial cells by way of Ca2+ influx and release from intracellular stores. We tested the hypothesis that SP-induced Ca2+ influx occurs due to activation of a Ca(2+)-permeable influx pathway coupled to depletion of intracellular stores. With the use of the perforated patch technique and fura 2 microfluorimetry, a fivefold greater increase in [Ca2+]i per unit decrease in membrane… CONTINUE READING
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