Substance P increases sympathetic activity during combined angiotensin-converting enzyme and dipeptidyl peptidase-4 inhibition.

@article{Devin2014SubstancePI,
  title={Substance P increases sympathetic activity during combined angiotensin-converting enzyme and dipeptidyl peptidase-4 inhibition.},
  author={Jessica K. Devin and Mias Pretorius and Hui Nian and Chang Yu and Frederic T. Billings and Nancy J. Brown},
  journal={Hypertension},
  year={2014},
  volume={63 5},
  pages={951-7}
}
UNLABELLED Dipeptidyl peptidase-4 inhibitors prevent the degradation of incretin hormones and reduce postprandial hyperglycemia in patients with type 2 diabetes mellitus. Dipeptidyl peptidase-4 degrades other peptides with a penultimate proline or alanine, including bradykinin and substance P, which are also substrates of angiotensin-converting enzyme (ACE). During ACE inhibition, substance P is inactivated primarily by dipeptidyl peptidase-4, whereas bradykinin is first inactivated by… CONTINUE READING
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