Substance P in heart failure: the good and the bad.

@article{Dehlin2014SubstancePI,
  title={Substance P in heart failure: the good and the bad.},
  author={Heather M Dehlin and Scott P Levick},
  journal={International journal of cardiology},
  year={2014},
  volume={170 3},
  pages={270-7}
}
The tachykinin, substance P, is found primarily in sensory nerves. In the heart, substance P-containing nerve fibers are often found surrounding coronary vessels, making them ideally situated to sense changes in the myocardial environment. Recent studies in rodents have identified substance P as having dual roles in the heart, depending on disease etiology and/or timing. Thus far, these studies indicate that substance P may be protective acutely following ischemia-reperfusion, but damaging long… CONTINUE READING

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