Substance P fails to mimic vagally mediated nonadrenergic bronchodilation.

The ability of substance P to mimic vagally mediated nonadrenergic bronchodilation was assessed in vivo in anesthetized, paralyzed, artificially ventilated cats. Infusion of the peptide at a rate of 10 micrograms kg-1 min-1 for 10 minutes did not attenuate the increase in pulmonary resistance evoked by efferent vagal stimulation. Similarly, when… CONTINUE READING