Substance P excites GABAergic neurons in the mouse central amygdala through neurokinin 1 receptor activation.

@article{Sosulina2015SubstancePE,
  title={Substance P excites GABAergic neurons in the mouse central amygdala through neurokinin 1 receptor activation.},
  author={Ludmila Sosulina and Christine Strippel and Héctor Romo-Parra and A. Walter and Tatyana G. Kanyshkova and Simone B. Sartori and Maren Denise Lange and Nicolas Singewald and Hans-Christian Pape},
  journal={Journal of neurophysiology},
  year={2015},
  volume={114 4},
  pages={
          2500-8
        }
}
Substance P (SP) is implicated in stress regulation and affective and anxiety-related behavior. Particularly high expression has been found in the main output region of the amygdala complex, the central amygdala (CE). Here we investigated the cellular mechanisms of SP in CE in vitro, taking advantage of glutamic acid decarboxylase-green fluorescent protein (GAD67-GFP) knockin mice that yield a reliable labeling of GABAergic neurons, which comprise 95% of the neuronal population in the lateral… Expand
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References

SHOWING 1-10 OF 90 REFERENCES
Substance P inhibits GABAB receptor signalling in the ventral tegmental area
TLDR
Investigating the mechanisms underlying SP actions in the VTA shows that in VTA neurons, NK receptor activation closes an inwardly rectifying potassium channel, and moreover inhibits GABAB receptor‐mediated transmission through an interaction that depends upon phospholipase C, intracellular calcium and protein kinase C (PKC). Expand
Anxiety-like behavior is modulated by a discrete subpopulation of interneurons in the basolateral amygdala
TLDR
The phenotypic and regional selectivity of the lesions was confirmed, and the extent to which the NK(1r) cells of amygdala nuclei contribute to anxiety-like responses was also investigated. Expand
Substance P in the medial amygdala: Emotional stress-sensitive release and modulation of anxiety-related behavior in rats
TLDR
The MeA is identified as a critical brain area for the involvement of SP transmission in anxiety responses and as a putative site of action for the recently discovered therapeutic effects of SP antagonists in the treatment of stress-related disorders. Expand
Neurokinin-1 Receptor-Expressing Neurons in the Amygdala Modulate Morphine Reward and Anxiety Behaviors in the Mouse
TLDR
It is suggested that the amygdala is an important area for the effects of SP and the NK1 receptor in the motivational properties of opiates, as well as the control of behaviors related to anxiety. Expand
Substance P stimulates inhibitory synaptic transmission in the guinea pig basolateral amygdala in vitro
TLDR
A physiological role for SP in the regulation of pathways involved in the control of emotional behaviour is supported, and immunohistochemistry revealed NK1 receptor immunoreactivity to be largely restricted to a subset of GABA interneurones. Expand
Subpopulations of neurokinin 1 receptor-expressing neurons in the rat lateral amygdala display a differential pattern of innervation from distinct glutamatergic afferents
TLDR
The data add to previous localization studies by describing an unexpected variation between LA and basal nucleus of the amygdala (BA) in the neurochemical phenotype of NK1-expressing neurons and reveal the relative source of glutamatergic inputs that may activate these neurons, which in turn regulate fear and anxiety responses. Expand
Effects of Substance P in the Amygdala, Ventromedial Hypothalamus, and Periaqueductal Gray on Fear-Potentiated Startle
TLDR
It is suggested that multiple outputs from the amygdala play a critical role in fear-potentiated startle and that SP plays a critical, probably modulatory role, in the MeA to VMH to PAG to the startle pathway based on these and data from others. Expand
Neurosteroids increase tonic GABAergic inhibition in the lateral section of the central amygdala in mice.
TLDR
Evidence is provided for the existence of tonic GABAergic inhibition generated by the activation of δ-subunit-containing GABA(A)Rs in neurons of the lateral section of the mouse central amygdala (CeAl) and it is shown that neurosteroids play an important role in the modulation of tonics inhibitory signaling in the CeAl. Expand
Postsynaptic actions of substance P on rat periaqueductal grey neurons in vitro
TLDR
Results indicate that substance P acts via NK1, NK2 and NK3 receptors to excite subpopulations of opioid-sensitive and insensitive PAG neurons by increasing a non-selective cation conductance and by reducing a K- current, and has anti-opioid actions that are largely mediated by a reduction in the opioid induced K+ current. Expand
Physiological properties of central medial and central lateral amygdala neurons.
TLDR
The physiological properties of CE medial and CE lateral amygdala neurons are characterized using whole cell recordings in brain slices maintained in vitro to indicate that the CE nucleus contains several types of neurons endowed with distinct physiological properties. Expand
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