Substance P content and preprotachykinin gene-I mRNA expression in a rat model of chronic bronchitis.

@article{Killingsworth1996SubstancePC,
  title={Substance P content and preprotachykinin gene-I mRNA expression in a rat model of chronic bronchitis.},
  author={Cheryl R. Killingsworth and Joseph D. Paulauskis and Stephanie A. Shore},
  journal={American journal of respiratory cell and molecular biology},
  year={1996},
  volume={14 4},
  pages={
          334-40
        }
}
Chronic exposure of rats to high concentrations of SO2 gas induces a syndrome similar to human chronic bronchitis. The aim of these studies was to determine if substance P (SP) content in the trachea or lungs was elevated in this animal model of chronic bronchitis, and whether an increase in SP content was associated with an increase in preprotachykinin gene-I (PPT) mRNA expression. Rats were exposed to air (controls) or 250 ppm SO2 gas, 5 h per day, 5 days per week, for a period of 4 wk… CONTINUE READING
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