Substance P antagonist blocks leakage and reduces activation of cytokine-stimulated rat brain endothelium.

@article{Annunziata2002SubstancePA,
  title={Substance P antagonist blocks leakage and reduces activation of cytokine-stimulated rat brain endothelium.},
  author={Pasquale Annunziata and Chiara Cioni and Riccardo Santonini and Eugenio Paccagnini},
  journal={Journal of neuroimmunology},
  year={2002},
  volume={131 1-2},
  pages={41-9}
}
We recently demonstrated that substance P mediates increased permeability of brain endothelium exposed to HIV-1 gp120. To test whether substance P is involved in immune processes at the blood-brain barrier (BBB), we stimulated rat brain endothelial cultures prepared from cerebral microvessels with Interferon-gamma (IFN-gamma) and Tumor necrosis factor-alpha (TNF-alpha), two proinflammatory cytokines that alter the BBB and measured permeability to albumin and expression of adhesion molecule ICAM… CONTINUE READING
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