Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes.

@article{Lai2001SubstancePA,
  title={Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes.},
  author={J P Lai and W. Z. Ho and Guanxia Zhan and Y Yi and Ronald G. Collman and Steven D. Douglas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 7},
  pages={3970-5}
}
Substance P (SP) is a potent modulator of neuroimmunoregulation. We recently reported that human immune cells express SP and its receptor. We have now investigated the possible role that SP and its receptor plays in HIV infection of human mononuclear phagocytes. SP enhanced HIV replication in human blood-isolated mononuclear phagocytes, whereas the nonpeptide SP antagonist (CP-96,345) potently inhibited HIV infectivity of these cells in a concentration-dependent fashion. CP-96,345 prevented the… CONTINUE READING