Substance P and capsaicin release prostaglandin E2 from rat intrapulmonary bronchi.

@article{Szarek1998SubstancePA,
  title={Substance P and capsaicin release prostaglandin E2 from rat intrapulmonary bronchi.},
  author={John L Szarek and Beverly Spurlock and Carl A. Gruetter and Sally Lemke},
  journal={The American journal of physiology},
  year={1998},
  volume={275 5 Pt 1},
  pages={L1006-12}
}
We hypothesized that substance P and capsaicin would cause the release of prostaglandin E2(PGE2) from intrapulmonary bronchi isolated from Sprague-Dawley rats. Substance P (1 μM) caused the release of PGE2, measured with enzyme immunoassay, from the isolated airway segments; PGE2 release was inhibited by the neurokinin (NK)1-receptor antagonist, RP-67580, by inhibition of cyclooxygenase with meclofenamate, and by removal of the epithelium. The release of PGE2 caused by capsaicin (1 μM) was… CONTINUE READING