Substance P and Neurokinin 1 receptor - expression is affected in the ileum of mice with mutation in the W locus

@inproceedings{FaussonePellegrini2006SubstancePA,
  title={Substance P and Neurokinin 1 receptor - expression is affected in the ileum of mice with mutation in the W locus},
  author={Maria-Simonetta Faussone-Pellegrini and Maria-Giuliana Vannucchi},
  booktitle={Journal of cellular and molecular medicine},
  year={2006}
}
The tachykinin substance P (SP) acts on the gut muscle coat via its preferred receptor, neurokinin 1 (NK1r). In the mouse ileum, NK1r-immunoreactivity (NK1r-IR) was detected in neurons, in the interstitial cells of Cajal at the deep muscular plexus (ICC-DMP) and the myoid cells of the villi. SP-IR was detected in neurons and varicose nerve fibers, which were especially numerous at the DMP and closely associated with the ICC-DMP. In mice with a mutation in the W locus (ckit mutant animals… CONTINUE READING

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