Substance P analogs displace sigma binding differentially in the brain and spinal cord of the adult mouse

@article{Mousseau1994SubstancePA,
  title={Substance P analogs displace sigma binding differentially in the brain and spinal cord of the adult mouse},
  author={Darrell D. Mousseau and Alice A. Larson},
  journal={Metabolic Brain Disease},
  year={1994},
  volume={9},
  pages={249-255}
}
We have previously observed similarities in the behavioral effects produced by the NH2-terminus of the undecapeptide substance P (SP) and by 1,3-di(2-tolyl)-guanidine (DTG) in the adult mouse. The present series of experiments indicate differences in the rank-order of potency of sigma ligands [DTG; haloperidol (HAL)], SP analogs [SP; SP(1-7); SP(5-11); [D-Pro2, D-Phe7]-SP(1-7) (D-SP(1-7))] and miscellaneous compounds [morphine (MOR), naloxone (NAL)] at competing for [3H]-DTG binding sites in… CONTINUE READING