Substance P afferents from the habenula innervate the dorsal raphe nucleus

  title={Substance P afferents from the habenula innervate the dorsal raphe nucleus},
  author={Leonard M. Neckers and Joan P. Schwartz and Richard Jed Wyatt and Samuel G Speciale},
  journal={Experimental Brain Research},
The lateral habenula nuclei of the diencephalon innervate the median and dorsal raphe nuclei of the brainstem. Habenula lesions lead to decreased substance P levels in the dorsal but not median raphe within 24 hours. From this data, we propose a peptidergic innervation of the dorsal raphe nucleus by the habenula nuclei. 


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