Substance P activates rat colonic motility via excitatory and inhibitory neural pathways and direct action on muscles.

Abstract

We studied effects of nicotinic, muscarinic, serotoninergic, dopaminergic, adrenergic, vasoactive intestinal peptide (VIP) antagonists, VIP, nitric oxide-synthase inhibitors and stimulators alone and in combination with tetrodotoxin on substance P (SP)-stimulated intraluminal tone of the isolated proximal, middle and distal rat colon. Tetrodotoxin… (More)

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Cite this paper

@article{Scheurer1994SubstancePA, title={Substance P activates rat colonic motility via excitatory and inhibitory neural pathways and direct action on muscles.}, author={Ulrich Scheurer and E. Drack and Fred Halter}, journal={The Journal of pharmacology and experimental therapeutics}, year={1994}, volume={271 1}, pages={7-13} }