Substance P Weights Striatal Dopamine Transmission Differently within the Striosome-Matrix Axis.

@article{Brimblecombe2015SubstancePW,
  title={Substance P Weights Striatal Dopamine Transmission Differently within the Striosome-Matrix Axis.},
  author={Katherine R Brimblecombe and Stephanie J Cragg},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 24},
  pages={9017-23}
}
The mammalian striatum has a topographical organization of input-output connectivity, but a complex internal, nonlaminar neuronal architecture comprising projection neurons of two types interspersed among multiple interneuron types and potential local neuromodulators. From this cellular melange arises a biochemical compartmentalization of areas termed striosomes and extrastriosomal matrix. The functions of these compartments are poorly understood but might confer distinct features to striatal… CONTINUE READING