Substance P Causes Seizures in Neurocysticercosis

@inproceedings{Robinson2012SubstancePC,
  title={Substance P Causes Seizures in Neurocysticercosis},
  author={Prema Robinson and Armandina Garza and Joel V. Weinstock and Jose A. Serpa and Jerry Clay Goodman and Kristian T. Eckols and Bahrom Firozgary and David J Tweardy},
  booktitle={PLoS pathogens},
  year={2012}
}
Neurocysticercosis (NCC), a helminth infection of the brain, is a major cause of seizures. The mediators responsible for seizures in NCC are unknown, and their management remains controversial. Substance P (SP) is a neuropeptide produced by neurons, endothelial cells and immunocytes. The current studies examined the hypothesis that SP mediates seizures in NCC. We demonstrated by immunostaining that 5 of 5 brain biopsies from NCC patients contained substance P (SP)-positive (+) cells adjacent to… CONTINUE READING
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