Substance P (neurokinin 1) receptor antagonists enhance dorsal raphe neuronal activity.

@article{Conley2002SubstanceP,
  title={Substance P (neurokinin 1) receptor antagonists enhance dorsal raphe neuronal activity.},
  author={Rachel K Conley and Michael J. Cumberbatch and G. S. Mason and David J. Williamson and Timothy Harrison and Karen Locker and Christopher Swain and Karen Maubach and Ruth O'Donnell and Michael Rigby and Louise Hewson and David M. D. Smith and Nadia Melanie Rupniak},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 17},
  pages={
          7730-6
        }
}
Substance P receptor [neurokinin 1 (NK1] antagonists (SPAs) represent a novel mechanistic approach to antidepressant therapy with comparable clinical efficacy to selective serotonin reuptake inhibitors (SSRIs). Because SSRIs are thought to exert their therapeutic effects by enhancing central serotonergic function, we have examined whether SPAs regulate neuronal activity in the dorsal raphe nucleus (DRN), the main source of serotonergic projections to the forebrain. Using in vivo… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

The role of substance P in stress and anxiety responses

VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression

M. Rochea, D. M. Kerra, S. P. Huntc, J. P. Kellyb
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL