Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R).

@article{Chernova2009SubstanceP,
  title={Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R).},
  author={Irene Chernova and Jian-ping Lai and Haiying Li and Lynnae Schwartz and Florin Tuluc and Helen M. Korchak and Steven D. Douglas and Laurie E. Kilpatrick},
  journal={Journal of leukocyte biology},
  year={2009},
  volume={85 1},
  pages={154-64}
}
Substance P (SP) is a potent modulator of monocyte/macrophage function. The SP-preferring receptor neurokinin-1 receptor (NK1R) has two forms: a full-length NK1R (NK1R-F) isoform and a truncated NK1R (NK1R-T) isoform, which lacks the terminal cytoplasmic 96-aa residues. The distribution of these receptor isoforms in human monocytes is not known. We previously identified an interaction among SP, NK1R, and HIV viral strains that use the chemokine receptor CCR5 as a coreceptor, suggesting… CONTINUE READING

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