Substance P (Neurokinin-1) antagonist prevents postoperative vomiting after abdominal hysterectomy procedures.

@article{Gesztesi2000SubstanceP,
  title={Substance P (Neurokinin-1) antagonist prevents postoperative vomiting after abdominal hysterectomy procedures.},
  author={Z Gesztesi and Phillip E. Scuderi and Paul F. White and Wendy Wright and Ronald H Wender and Robert N D'Angelo and Linda S Black and Patricia L. Dalby and D S MacLean},
  journal={Anesthesiology},
  year={2000},
  volume={93 4},
  pages={931-7}
}
BACKGROUND The safety and antiemetic efficacy of CP-122,721, a novel neurokinin-1 antagonist, was evaluated when administered alone or in combination with ondansetron. METHODS Using a randomized, double-blind, placebo-controlled study design, CP-122,721 was initially compared with placebo and subsequently to ondansetron alone and in combination for prophylaxis against postoperative nausea and vomiting in 243 women undergoing abdominal hysterectomy. In the dose-ranging studies (n = 86… CONTINUE READING

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