Substance P: Model studies of its binding to phospholipids

  title={Substance P: Model studies of its binding to phospholipids},
  author={Fred Lembeck and Alois Saria and Norbert Mayer},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
1. The partition of substance P (SP) between buffer solutions (pH 1.6–7.8) and an organic, phospholipid (phosphatidyl serine, phosphatidyl ethanolamine, phosphatidyl inositol and phosphatidyl choline) containing phase (chloroform:methanol 2:1) was studied. 2. The binding of SP to phosphatidyl serine, phosphatidyl ethanolamine and phosphatidyl inositol was lowest at pH 2 and increased with pH. The binding to phosphatidyl choline was much smaller and less dependent on pH. 3. In contrast to the… CONTINUE READING


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