Substance P(1-7) antagonizes substance P-induced aversive behaviour in mice.

@article{Sakurada1988SubstancePA,
  title={Substance P(1-7) antagonizes substance P-induced aversive behaviour in mice.},
  author={Tsukasa Sakurada and Hiroo Kuwahara and Kou Takahashi and Shinobu Sakurada and Kensuke Kisara and Lars Terenius},
  journal={Neuroscience letters},
  year={1988},
  volume={95 1-3},
  pages={281-5}
}
Substance P (SP) and its fragments were administered intrathecally into awake mice. SP and C-terminal fragments caused dose-dependent reciprocal hindlimb scratching responses. SP(5-11) was more potent than SP not only in inducing scratching response but also in inducing aversive behaviour including licking and biting. SP(1-7) induced no behavioural reactions. However, when low doses of SP(1-7) (1.0-4.0 pmol) were injected simultaneously with SP or SP(5-11) (0.1 nmol), aversive behaviours… CONTINUE READING