Substance K and substance P in the ventral tegmental area.

  title={Substance K and substance P in the ventral tegmental area.},
  author={P W Kalivas and Ariel Y. Deutch and John E. Maggio and Patrick W Mantyh and Robert H. Roth},
  journal={Neuroscience letters},
  volume={57 3},
A comparison was made between substance P (SP) and substance K (SK) in the ventral tegmental area (VTA) (A10 dopamine cell group) of the rat. Approximately equal densities of SP and SK-immunoreactive neuronal fibers were observed. However, while previous reports demonstrate negligible density of autoradiographically defined SP receptors in the VTA, we observed a high density of SK receptors. SK or SP was microinjected into the VTA, and changes in spontaneous motor activity were measured using a… CONTINUE READING

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