Subset specification of central serotonergic neurons

  title={Subset specification of central serotonergic neurons},
  author={Marten P Smidt and Johannes A. van Hooft},
  booktitle={Front. Cell. Neurosci.},
The last decade the serotonin (5-hydroxytryptamine; 5-HT) system has received enormous attention due to its role in regulation of behavior, exemplified by the discovery that increased 5-HT tone in the central nervous system is able to alleviate affective disorders. Here, we review the developmental processes, with a special emphasis on subset specification, leading to the formation of the 5-HT system in the brain. Molecular classification of 5-HT neuronal groups leads to the definition of two… CONTINUE READING