• Corpus ID: 44906876

Subsensitivity of the presynaptic dopamine receptors in cat heart after the termination of chronic haloperidol treatment.

@article{Verimer1981SubsensitivityOT,
  title={Subsensitivity of the presynaptic dopamine receptors in cat heart after the termination of chronic haloperidol treatment.},
  author={T. Verimer and John Paul Long and Jan R. Flynn and Stephen Arneric and B. J. Walsh},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1981},
  volume={253 2},
  pages={
          233-40
        }
}
  • T. Verimer, J. P. Long, B. Walsh
  • Published 1 October 1981
  • Biology, Psychology, Chemistry
  • Archives internationales de pharmacodynamie et de therapie
The effects of chronic haloperidol treatment on presynaptic dopamine receptor sensitivity were studied on cat cardioaccelerator nerve terminals. Apomorphine and N, N-dimethyldopamine, two dopamine receptor agonists, caused inhibition of heart rate increase produced by postganglionic cardioaccelerator nerve stimulation. After termination of chronic haloperidol treatment, inhibition induced by apomorphine and N, N-dimethyldopamine was attenuated. The hypotensive and bradycardic effects of… 
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