Subretinal transplantation of rat MSCs and erythropoietin gene modified rat MSCs for protecting and rescuing degenerative retina in rats.

@article{Guan2013SubretinalTO,
  title={Subretinal transplantation of rat MSCs and erythropoietin gene modified rat MSCs for protecting and rescuing degenerative retina in rats.},
  author={Yijian Guan and Liwang Cui and Zhu-Ling Qu and Liang-Yu Lu and Fang Wang and Y-J Wu and Jingyue Zhang and Fan Gao and Haibin Tian and Liangcheng Xu and G-T Xu and Weiye Li and Yanling Jin},
  journal={Current molecular medicine},
  year={2013},
  volume={13 9},
  pages={
          1419-31
        }
}
For degenerative retinal diseases, like the acquired form exemplified by age-related macular degeneration (AMD), there is currently no cure. This study was to explore a stem cell therapy and a stem cell based gene therapy for sodium iodate (SI)-induced retinal degeneration in rats. Three cell types, i.e., rat mesenchymal stem cells (rMSCs) alone, erythropoietin (EPO) gene modified rMSCs (EPO-rMSCs) or doxycycline (DOX) inducible EPO expression rMSCs (Tet-on EPO-rMSCs), were transplanted into… CONTINUE READING
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