Subregional neuroanatomical change as a biomarker for Alzheimer's disease.

  title={Subregional neuroanatomical change as a biomarker for Alzheimer's disease.},
  author={Dominic Holland and James B. Brewer and Donald J. Hagler and Christine Fennema-Notestine and Anders M. Dale},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 49},
Regions of the temporal and parietal lobes are particularly damaged in Alzheimer's disease (AD), and this leads to a predictable pattern of brain atrophy. In vivo quantification of subregional atrophy, such as changes in cortical thickness or structure volume, could lead to improved diagnosis and better assessment of the neuroprotective effects of a therapy. Toward this end, we have developed a fast and robust method for accurately quantifying cerebral structural changes in several cortical and… CONTINUE READING


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