Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice.

  title={Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice.},
  author={Josien Levenga and Femke M S de Vrij and Ronald A. M. Buijsen and Tracy T Li and Ingeborg M. Nieuwenhuizen and Andreea S. Pop and Ben A. Oostra and Rob Willemsen},
  journal={Neurobiology of learning and memory},
  volume={95 4},
Fragile X syndrome (FXS) is the most common inherited form of mental retardation and is caused by the lack of fragile X mental retardation protein (FMRP). In the brain, spine abnormalities have been reported in both patients with FXS and Fmr1 knockout mice. This altered spine morphology has been linked to disturbed synaptic transmission related to altered signaling in the excitatory metabotropic glutamate receptor 5 (mGluR5) pathway. We investigated hippocampal protrusion morphology in adult… CONTINUE READING
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